Biosynthesis of ovarian steroids

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Prostaglandin F 2α (PGF 2α ) did not alter the in vitro biosynthesis of progesterone by slices of luteinized rat ovaries when used in concentrations from 1 to 10,000 ng/ml of incubation medium; likewise, PGF 2α did not affect the incorporation of acetate-1- 14 C into progestins. PGF 1α , 15-keto PGF 2α , and PGE 1 did not alter the biosynthesis of progesterone by luteinized rat ovaries; PGE 2 inhibited the production of progesterone when used at a concentration of 10 μg/ml, but not at lower doses. PGF 2α in combination with luteinizing hormone (LH) enhanced the metabolism of progesterone to 20α-hydroxypregn-4-en-3-one in luteinized rat ovaries. Interestingly, PGF 2α , at a high concentration of 10 μg/ml, did stimulate progesterone biosynthesis by slices of ovarian tissue from immature rats hormonally primed to simulate “pseudopregnancy,” suggesting a steroidogenic action of prostaglandins on the ovarian follicular or interstitial cell. PGF 2α (10 μg/ml) did not stimulate the in vitro biosynthesis of progesterone or 20α-hydroxypregn-4-en-3-one by slices of rabbit corpora lutea or rabbit ovarian interstitial tissue. It is concluded that prostaglandins do not stimulate progestin biosynthesis in rat luteal tissue.

Biosynthesis of ovarian steroids

biosynthesis of ovarian steroids


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