Transdermal patches can be a very precise time released method of delivering a drug. Cutting a patch in half might affect the dose delivered. The release of the active component from a transdermal delivery system (patch) may be controlled by diffusion through the adhesive which covers the whole patch, by diffusion through a membrane which may only have adhesive on the patch rim or drug release may be controlled by release from a polymer matrix. Cutting a patch might cause rapid dehydration of the base of the medicine and affect the rate of diffusion.
The international scientific research study ” The response of phimosis to local steroid application” by CS Kikiros, SW Beasley, and AA Woodward at the Department of General Surgery, Royal Children’s Hospital in Australia, analysed the effect of phimosis ointment treatments (three different types) applied to a juvenile cohort (up to 16 years) with varying degrees of congenital phimosis. The conclusion of the group analysis was that local application of a steroid ointment to the foreskin produced resolution of juvenile congenital phimosis in over 60% of cases, but if the foreskin had a circumferential white scar ( phimotic ring ), this was less likely to respond to treatment. After cessation of the cream with steroids, the phimosis developed again in a percentage of patients.