Several important peptide hormones are secreted from the pituitary gland. The anterior pituitary secretes three hormones: prolactin , which acts on the mammary gland ; adrenocorticotropic hormone (ACTH), which acts on the adrenal cortex to regulate the secretion of glucocorticoids ; and growth hormone , which acts on bone , muscle , and the liver . The posterior pituitary gland secretes antidiuretic hormone , also called vasopressin, and oxytocin . Peptide hormones are produced by many different organs and tissues, including the heart ( atrial-natriuretic peptide (ANP) or atrial natriuretic factor (ANF)) and pancreas ( glucagon , insulin and somatostatin ), the gastrointestinal tract ( cholecystokinin , gastrin ), and adipose tissue stores ( leptin ).  
Bioidentical progesterone cream is easily and quickly absorbed into the body so you can apply it almost anywhere with success.
We recommend that you rotate the areas to avoid saturating any one area. It is best absorbed where the skin is relatively thin and well supplied with capillary blood flow, such as the upper chest, breasts and inner thighs or inner arms.
Massage the progesterone cream into your skin until it is noticeably absorbed. Progesterone should not be applied over top of other body creams or perfumes as they may interfere with proper and ideal absorption.
Menopausal or Post-Menopausal Women:
Apply progesterone cream twice a day for a maximum of 25 consecutive days. Resume after a five-day break. After you have received significant relief you can and should see if your body can do as well with one application a day, most women can simply apply it once a day after this time and receive the same relief.
Apply progesterone cream once or twice daily as needed, starting on the 7th day after the first day of menstrual flow thru the 27th day.
Apply the progesterone cream once or twice a day as needed, starting on the 12th day after the first day of menstrual flow thru the 27th day.
Premenstrual Irritability :
We recommend you try progensa 20 progesterone without the phytoestrogens first and if this does not give you satisfactory relief than try progensa plus progesterone with phytoestrogens.
The secretion of hypothalamic, pituitary, and target tissue hormones is under tight regulatory control by a series of feedback and feed- forward loops. This complexity can be demonstrated using the growth hormone (GH) regulatory system as an example. The stimulatory substance growth hormone releasing hormone (GHRH) and the inhibitory substance somatostatin (SS) both products of the hypothalamus, control pituitary GH secretion. Somatostatin is also called growth hormone-inhibiting hormone (GHIH). Under the influence of GHRH, growth hormone is released into the systemic circulation, causing the target tissue to secrete insulin-like growth factor-1, IGF-1. Growth hormone also has other more direct metabolic effects; it is both hyperglycemic and lipolytic. The principal source of systemic IGF-1 is the liver, although most other tissues secrete and contribute to systemic IGF-1. Liver IGF-1 is considered to be the principal regulator of tissue growth. In particular, the IGF-1 secreted by the liver is believed to synchronize growth throughout the body, resulting in a homeostatic balance of tissue size and mass. IGF-1 secreted by peripheral tissues is generally considered to be autocrine or paracrine in its biological action.