The precise mechanism through which fluticasone propionate affects rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. In 7 trials in adults, fluticasone propionate nasal spray has decreased nasal mucosal eosinophils in 66% of patients (35% for placebo) and basophils in 39% of patients (28% for placebo). The direct relationship of these findings to long-term symptom relief is not known.
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Some side effects that may occur when using FLONASE ® , a nasal steroid, include burning, dryness, crusting, or other irritation inside the nose. 3 Other possible side effects of FLONASE ® include occasional nose bleeds, nasal whistling, and headaches. 4 If you experience symptoms while using FLONASE ® that resemble an allergic reaction such as rash, swelling of the face or tongue, wheezing, or feeling faint, stop using FLONASE ® and see a doctor. 4 If you have questions or concerns about symptoms or trouble using the medication it is best to call your doctor.