Non-steroidal aromatase inhibitors breast cancer

Oral administration of Anastrozole to female rats (from 2 weeks before mating to pregnancy day 7) produced significant incidence of infertility and reduced numbers of viable pregnancies at 1 mg/kg/day (about 10 times the recommended human dose on a mg/m 2 basis and 9 times higher than the AUC 0-24 hr found in postmenopausal volunteers at the recommended dose). Pre-implantation loss of ova or fetus was increased at doses equal to or greater than mg/kg/day (about one-fifth the recommended human dose on a mg/m 2 basis). Recovery of fertility was observed following a 5-week non-dosing period which followed 3 weeks of dosing. It is not known whether these effects observed in female rats are indicative of impaired fertility in humans.

Non-steroidal aromatase inhibitors breast cancer

non-steroidal aromatase inhibitors breast cancer

Media:

non-steroidal aromatase inhibitors breast cancernon-steroidal aromatase inhibitors breast cancernon-steroidal aromatase inhibitors breast cancernon-steroidal aromatase inhibitors breast cancernon-steroidal aromatase inhibitors breast cancer

http://buy-steroids.org