Steroid taper ulcerative colitis

"I was hospitalized three times last year for ulcerative colitis and severe anemia. I had tried asacol, sulfasalazine and nothing worked. I was afraid to try the prednisone and when I finally did, it helped immediately. I could kick myself for waiting so long and almost dying from blood loss before I got It. The side effects that I had were insomnia, feeling wired and roid ragey, and after 7 months on it I gained around 50 lbs. It gives you the mad munchies. It's not long term fix because of the long term health risks, diabetes, vision loss, hump neck, weight gain and it also suppresses your immune system. Remicaid worked for me while I was on prednisone, but once I tapered off I had the most terrible joint pain and arthralgia and edema."

BioCure hopes to have TSO approved by regulators and on the market in Europe by May 2005. Some scientists have long believed that the eradication of worms from human stomachs over the past 50 years may be behind the rise in IBD. Dr. Weinstock, a gastroenterologist at the University of Iowa, came up with the TSO idea after noticing that a rise in IBD cases coincided with a drop in infections caused by roundworms and human whipworms. IBD is rare in developing countries where parasitic infections are more common. When TSO was tested twice a month on 100 IBD patients, symptoms such as abdominal pain, bleeding and diarrhea disappeared. Fifty percent of patients with ulcerative colitis and 70 percent of Crohn’s sufferers went into remission.

In cerebral edema , Dexamethasone Sodium Phosphate injection, USP is generally administered initially in a dosage of 10 mg intravenously followed by 4 mg every six hours intramuscularly until the symptoms of cerebral edema subside. Response is usually noted within 12 to 24 hours and dosage may be reduced after two to four days and gradually discontinued over a period of five to seven days. For palliative management of patients with recurrent or inoperable brain tumors, maintenance therapy with either Dexamethasone Sodium Phosphate injection, USP or dexamethasone tablets in a dosage of 2 mg two or three times daily may be effective. Dexamethasone suppression tests:

Braun et al (2002) reported the results of a 12-week randomized placebo-controlled clinical trial involving 35 patients with active ankylosing spondylitis treated with intravenous 5 mg/kg infliximab infusion (at weeks 0, 2 and 6) and 35 patients assigned to placebo.  Eighteen (53 %) of 34 patients on infliximab had a regression of disease activity at week 12 of at least 50 % compared with 3 (9 %) of 35 on placebo (difference 44 % (95 % confidence interval [CI]: 23 to 61, p < ).  Function and quality of life also improved significantly on infliximab but not on placebo (p < and p < , respectively).  The investigators reported that treatment with infliximab was generally well-tolerated, but 3 patients had to stop treatment because of systemic tuberculosis, allergic granulomatosis of the lung, or mild leucopenia.

Steroid taper ulcerative colitis

steroid taper ulcerative colitis

Braun et al (2002) reported the results of a 12-week randomized placebo-controlled clinical trial involving 35 patients with active ankylosing spondylitis treated with intravenous 5 mg/kg infliximab infusion (at weeks 0, 2 and 6) and 35 patients assigned to placebo.  Eighteen (53 %) of 34 patients on infliximab had a regression of disease activity at week 12 of at least 50 % compared with 3 (9 %) of 35 on placebo (difference 44 % (95 % confidence interval [CI]: 23 to 61, p < ).  Function and quality of life also improved significantly on infliximab but not on placebo (p < and p < , respectively).  The investigators reported that treatment with infliximab was generally well-tolerated, but 3 patients had to stop treatment because of systemic tuberculosis, allergic granulomatosis of the lung, or mild leucopenia.

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