After the double-murder suicide, former wrestler Christopher Nowinski contacted Benoit's father, suggesting that years of trauma to his son's brain may have led to his actions. Tests were conducted on Benoit's brain by Julian Bailes, the head of neurosurgery at West Virginia University, and results showed that "Benoit's brain was so severely damaged it resembled the brain of an 85-year-old Alzheimer's patient." He was reported to have had an advanced form of dementia, similar to the brains of four retired NFL players who had suffered multiple concussions, sank into depression, and harmed themselves or others. Bailes and his colleagues concluded that repeated concussions can lead to dementia, which can contribute to severe behavioral problems.
Gynecomastia is a common adverse effect of bicalutamide (Casodex) therapy that may prompt some men to discontinue prostate cancer treatment. Tamoxifen has been recommended as a preventive agent for gynecomastia in these patients. A double-blind study of 282 men randomized to receive 20 mg of tamoxifen once per day with bicalutamide or bicalutamide alone found that after six months, gynecomastia and breast pain were significantly reduced in men who received tamoxifen ( versus percent in the control group). 41 An Italian randomized controlled trial of 80 participants also found that 20 mg of tamoxifen once per week is as effective as 20 mg once per day. 42